*Corresponding Author: Tenzin Dadul: Post graduate student, Department of Oral Medicine and Radiology Saveetha Dental College Poonamallee High Road, Vellappanchavadi Chennai- 600 077 India
Oral submucous fibrosis is a chronic, insidious disease that is associated with significant functional morbidity and an increased risk of malignancy. The role of the constituents of areca nut in the pathogenesis of oral submucous fibrosis has been studied in detail over the last two decades. It is apparent that among the chemical constituents, alkaloids from areca nut are the most important biologically and arecoline is one of them. Relevant studies have also reported the association between copper and oral submucous fibrosis. The possible role of copperas a mediator in oral submucous fibrosis can be explained by the upregulation of enzyme lysyl oxidase which is copper dependent.
Structured electronic and hand search of scientific papers were carried out. Electronic search on Oral submucous fibrosis literature included Pub Med and Science Direct using key words. The search resulted to 611 papers, out of which 24 were identified as conforming to the inclusion criteria. Hand search yielded 5 relevant papers. Papers that did not include arecoline and copper as the etiologic factors were not includedin this review. Total of 24 papers form the basis for the present systematic review.
The systematic search revealed 611 articles of which 24 articles met inclusion criteria. 21 articles revealed that are coline induce oral submucous fibrosis and 3 articles revealed that copperas mediator of oral submucous fibrosis.
This review revealed that both are coline and copper plays a vital role in the etiopathogenesis of oral submucous fibrosis.
Oral submucous fibrosis, are coline, are coline hydrobromide, copper, copper chloride
