1Department of Oral Medicine and Radiology, Subharti Dental College, Subhati University, Meerut, U.P, India
2Department of Oral Medicine and Radiology, Govt. Dental College and Hospital, Ahmedabad, Gujarat, India
*Correspondence Address: Dr Swati Gupta, Department Of Oral Medicine and Radiology, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, drswatig@rediffmail.com
Online published on 1 August, 2013.
Proliferative verrucous leukoplakia (PVL) is an aggressive form of oral leukoplakia with multifocal presentation, high rates of recurrence and malignant transformation. PVL is an uncommon variant of leukoplakia.
12 patients clinically diagnosed as proliferative verrucous leukoplakia in the department of Oral Diagnosis, Government Dental College and Hospital, Ahmedabad were studied with reference to their clinic-pathologic correlation. A total of 19 lesions were biopsied in these 12 patients.
Histopathologically, Verrucous hyperplasia without dysplasia was seen in 11 lesions (57.89%), verrucous hyperplasia with dysplasia in 4(21.05%), verrucous carcinoma in one (5.26%), squamous cell carcinoma in 3(15.7%).
It is concluded that PVL is a clinical entity with histopathologic progression over years ranging from hyperkeratosis, papillomatosis, pseudoepitheliomatous hyperplasia, to dysplasia, to verrucous carcinoma, or squamous cell carcinoma. Because of both the propensity for progression to dysplasia and malignancy, as well as a high recurrence rate, these patients must be treated aggressively and followed carefully.
Proliferative verrucous leukoplakia (PVL), verrucous leukoplakia, verrucous carcinoma; verrucous hyperplasia, squamous cell carcinoma, epithelial dysplasia
