Department of Oral Pathology and Microbiology DJ Dental College, Modinagar
*Address for correspondence: Dr. Amit Kumar Singh, Senior Lecturer, Dept. Of Oral Pathology, D.J. College of Dental Sciences, Modinagar (U.P.)
Online published on 7 December, 2013.
Oral cancer being one of the most common cancer, constitutes a major health problem in developing countries and accounts for 30–40 percent of all cancers in Indian subcontinent and patients with oral precancerous condition have also been reported to show a significant tendency to develop cancer. The aim of this study was to find out status of lipid profile in patients with oral precancerous lesion and condition which can be used in early diagnosis of oral precancerous lesion and condition. A hospital based randomized case control study was done among patients grouped into three categories 10 in each. Normal healthy individuals with no habit of tobacco chewing or smoking, Normal healthy individuals with habit of tobacco chewing and smoking and patients with clinically diagnosed oral precancerous lesion condition. Their fasting blood samples were analysed for plasma total cholesterol, High density lipoprotein (HDL), triglycerides and low density lipoprotein (LDL). The study showed significant decrease level of HDL cholesterol levels (p=.035) were observed in patients with oral precancerous lesion and condition. The reason for low HDL cholesterol level might be the consequence of disease that is mediated by its ulilization for membrane biogenesis.
Oral cancer, lipid profile, oral potentially malignant disorders
