1Postgraduate student, Department of Oral Medicine and Radiology, Nims Dental College, Jaipur
2Professor and Head, Department of Oral Medicine and Radiology, Nims Dental College, Jaipur
3Assisstant professor, Department of Oral Medicine and Radiology, Nims Dental College, Jaipur
Online published on 22 January, 2026.
Pemphigus Vulgaris (PV) is a disease of autoimmune origin that has the potential to be life threatening. It manifests as the development of blisters and erosions on the skin and mucous membranes, which are closely linked to intraepithelial acantholysis. Intraepithelial lesions are formed due to specific binding of immunoglobulin G autoantibodies to desmoglein 3, which is a transmembrane glycoprotein adhesion molecule present on desmosomes. The histological characteristics encompass the presence of intraepithelial clefts and Tzanck cells. Corticosteroids remain the mainstay of the treatment plan. This article encompasses a discussion on the diagnosis of patient suffering from Pemphigus Vulgaris, the treatment rendered, and the outcome of the same.
