1Amity Institute of Forensic Sciences, Amity University, Uttar Pradesh
2Amity Institute of Forensic Sciences, Amity University, Uttar Pradesh
3Forensic Science Laboratory, G.N.C.T, New Delhi
Arteether, a sesquiterpene artemisinin derivative is the first line of treatment of Malaria. Malaria is an endemic disease and is a major cause of mortality in developing nations like India, Africa etc. Although the drug is rapid acting but has some pernicious effects associated with it. The cases of drugs induced toxicity has arisen tremendously in the past few decades. This pernicious effect is attributed to over dosage and drug reactions. A simple method has been developed for extracting Arteether from vomit and gastric lavage. Drug residues were extracted from gastric lavage andvomit with the help of liquid- liquid extraction followed by protein precipitation to remove the fat residues. Drug residues obtained were separated by Agilent Gas chromatograph column and detected by mass selective detector (GC-MS). The method is found to be accurate, precise, sensitive and specific.
Arteether, Gastric lavage, GC-MS
