1Department of Forensic Medicine and Toxicology, Yenepoya deemed to be University, Mangalore, Dakshina Karnataka, India
2Department of Pathology, Yenepoya deemed to be University, Mangalore, Dakshina Karnataka, India
3Yenepoya Pharmacy College and Research centre, Yenepoya deemed to be University, Mangalore, Dakshina Karnataka, India
4Department of Forensic Medicine and Toxicology, Yenepoya deemed to be University, Mangalore, Dakshina Karnataka, India
*Corresponding Author: Dr. Hashim. A, Lecturer/Toxicologist, Department of Forensic Medicine and Toxicology, Yenepoya deemed to be University, Mangalore, Dakshina Karnataka, India Contact: +91 9742555052 Email: mhdhashim@gmail.com
Introduction: Several line of studies have indicated high concentrations of arsenic in the liver, kidney, brain, lungs, hair and nails. Epidemiological studies have shown association between chronic arsenic exposure liver disease, kidney failure and brain damage. Moreover, the pathological changes are poorly understood. Understanding the organ specific histological effect of arsenic is necessarily important to know the detailed mechanism of arsenic mediated toxicity in mammals.
Material and Method: This study was designed to evaluate the histopathological changes by chronic arsenic exposure on some tissue architecture in rats.
Results: These findings from animal model clearly indicate the possible role of arsenic in various diseases in human populations continuously being exposed to arsenic through drinking water as well as food. A better understanding of the effect of arsenic at target organs with an emphasis on observation of tissue architecture at critical sites may be useful to develop an effective drug for its treatment, where thousands ofpeople are suffering from arsenic poisoning.
Arsenic, Histopathology, Rat tissues
