Phenytoin Induced Steven Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) Overlap.

Steven Johnson Syndrome is an acute life threating, fatal drug reaction presenting as severe mucosal erosions with widespread erythematous, cutaneous macules or atypical targets. Majority of the cases are drug induced affecting oral and perioral region. A case of SJ S/TEN overlap following treatment with phenytoin is being presented here. A 30 year old male was put on phenytoin for epilepsy; he developed rashes, vesicle, bullae all over body associated with pain, itching, fever and purulent discharge from both eyes and ears after 10 days of treatment. The patient was managed by withdrawing of phenytoin immediately and treated with systemic corticosteroids, antimicrobial, antifungal and antihistamines.This case has been presented here to highlight the necessity of judicious use of widely prescribed antiepileptic phenytoin to prevent life threatening adverse drug reaction.