1Masters Student, Department of Forensic Science, Chandigarh University, Punjab, India
2Assistant Professor, Department of Forensic Science, Chandigarh University, Punjab, India
*Corresponding Author: Dr. Spriha Sharma, Assistant Professor, Department of Forensic Science, Chandigarh University, Punjab, India, E-mail: spriha.e11092@cumail.in, Contact : +91-9780612627
Online Published on 10 September, 2024.
Cough syrup is a liquid drug used to treat coughs and colds. It comprises several components such as cough suppressing substances in conjunction with various chemically active chemicals.
A thorough qualitative examination of various cough syrups was conducted in this study, in which 20 randomly selected cough syrup samples were analysed using proper Liquid-Liquid Solvent extraction protocol, followed by volatile profiling of the samples using Gas Chromatography tandem Mass Spectrometry.
The findings revealed 349 organic volatile components classified as Alcohols, Aldehydes & Ketones, Organic acids, Esters, Ethers, and other miscellaneous substances. A few analgesics (Dihydromorphine), semi-synthetic opioids (Dextromethorphan), and morphinans (Norlevorphanol) were also discovered but were not listed on the label. Because to its high efficiency and low error rates, we employed GCMS in this investigation to evaluate the organic volatile components contained in each sample.
GC-MS is effective, complementary techniques for the selective and sensitive quality control of cough syrups
Cough Syrups, Gcms, Solvent Extraction, Opioids, Volatile Profiling
