Biotechnology Centre, Indian Agricultural Research Institute, New Delhi-110 012, India
Present address: Director General, ICAR, Krishi Bhavan, New Delhi-110 001
An ado-mutation of strain WP2 trp-6 of E. coll B that lowers the spontaneous mutation rate Is described. Both the forward and back mutation rates are effected. Adenine added to the medium, however, is not able to abolish or reduce the antimutator effect. The mutagenlcity of UV and several chemical mutagens Is suppressed by the ade-mutation. The involvement of the mutation at different level of transfer of genetic information in the bacteria is examined and proposals are made regarding its mode of action.
adenine mutation, antimutator effect, Escherichia coli
