Effect of Paracetamol of the Pharmacokinetics of Cefuroxime in Buffalo Calves

The pharmacokinetics of cefuroxime administered with paracetamol, was investigated in buffalo calves. Cefuroxime was administered by single intravenous dose (10 mg/kg) and paracetamol was given by single intramuscular dose (50 mg/kg). Pharmacokinetics of cefuroxime was described by two compartment open model. The highest concentration of cefuroxime was 80.9 ± 6.40 µg/ml at 1 min, which decreased to 0.97 ± 0.07 µg/ml at 8 hr after its administration. The values of distribution half life, elimination half life and V_d(area) were 0.101 ± 0.009 hr, 1.91 ± 0.07 hr and 0.55 ± 0.12 L/kg, respectively. The dosage regimen of cefuroxime when administered with paracetamol was calculated to be 10 mg/kg body wt repeated at 8 hr intervals.