1Department of Biochemistry, Grant Medical College and Sir J J Group of Hospitals, Mumbai -400 008 (India) dr.rajeevj@gmail.com
2Department of General Surgery, Government Medical College, Miraj, Maharashtra (India)
*[Presently C-505, Beach Classic CHS Ltd. Near Gorai Pumping Station, Chikoowadi, Borivali (W), Mumbai-400 092 (India)]
To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.
A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, and after three and six months of therapy.
In pre-menopausal and postmenopausal patient's total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels were reduced significantly, whereas triglycerides (TGs), very low density lipoprotein-cholesterol (VLDL-C) and high density lipoprotein-cholesterol (HDL-C) were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-C was significantly higher at both 3 and 6 months in postmenopausal patients.
The study demonstrates that tamoxifen favorably alters the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.
Breast cancer, Tamoxifen therapy, Pre-menopausal, Postmenopausal, Plasma lipid profile.
