1Associate Professor, Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar - 143001, Punjab, India.
2Associate Professor, Department of Pharmacology, Government Medical College, Amritsar – 143001, Punjab, India.
P-Glycoprotein (P-gp) also known as MDR1, is one of the most extensively studied transporters in context of drug resistance and drug–drug interactions (DDIs). P-gp is expressed in multiple organs, such as small intestine, blood brain barrier, kidney and liver, influencing the pharmacokinetics of drugs. Chemicals that can interact with P-gp can be classified as substrates, modulators, inhibitors or inducers. Therefore, P-gp-mediated DDIs can occur at various organs and tissues. P-gp may lead to unpredictability in the drug disposition inside the body and knowledge of its specific interaction with a drug can be exploited for better drug disposition.
P-glycoprotein, Drug–drug interactions, Transporters, Expression, Drug resistance
