1Department of Veterinary Preventive Medicine, SKAUST, Jammu
2Department of Veterinary Pathology, SKAUST, Jammu
3Department of Livestock Production and Management, SKAUST, Jammu
4Department of Veterinary Pharmacology & Toxicology, CVASc, SKAUST, Jammu
5Department of Veterinary Public Health, AAU, Guwahati
Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Guwahati - 781 022, India
*Author for correspondence
Online published on 13 August, 2013.
In the present investigation, the effect of various neuropharmacological agents was studied on spontaneous muscular activity of Paramphistomum cervi. The cholinergic agonists (acetylcholine chloride, carbamylcholine, nicotine sulphate) and antagonist (atropine sulphate) was investigated at 10−7 M to 10−3M concentration and their effect on spontaneous muscular activity of the parasite was recorded. Acetylcholine chloride failed to modify the normal muscular activity while cholinergic agonists, carbamylcholine and nicotine sulphate caused reduction in amplitude, baseline tension and frequency of the isometrically mounted rumen fluke. However, atropine sulphate which acts as cholinergic antagonist produced dose dependent excitation of the rumen fluke.
Acetylcholine chloride, Carbamylcholine, Nicotine sulphate, Atropine sulphate, Paramphistomum cervi
