Levamisole and fenbendazole resistance among gastrointestinal nematodes in goats at Jabalpur, Madhya Pradesh

The present study was conducted to evaluate the efficacy of commonly used anthelmintics and to know the status of resistance against various anthelmintics in goats in an organized farm at Jabalpur. 75 goats were randomly assigned to five groups (I to V) of 15 animals each. Group I to IV were treated with ivermectin @ 0.2 mg/kg b.wt. subcutaneously (sc), levamisole @ 7.5 mg/kg b.wt. sc, fenbendazole @ 7.5 mg/kg b.wt. orally and closantel @ 10 mg/kg b.wt. orally, respectively. Group V served as untreated control. Eggs per gram (EPG) values were estimated before treatment and 10 days post treatment and faecal egg count reduction test (FECRT) was carried out. Resistance was detected against levamisole and fenbendazole, whereas ivermectin and closantel were 99% and 100% effective, respectively. This seems to be the first documentation of multiple anthelmintic resistance against gastrointestinal helminths in goats in the Central India. The treatment strategies need to be changed in the light of these findings to prevent further development of resistance.