Diet-induced modulation of albendazole biotransformation in goats

Influence of diet type and pre-treatment fasting on the kinetic disposition of albendazole was evaluated in goats following intraruminal administration of the drug. T_max, AUC and t1/2β for ABZ-SO were significantly higher (P<0.05) in goats receiving grasses with high dry matter content. Similarly, C_max, T_max, AUC and t1/2β for ABZ maxmax SO were significantly higher (P<0.05) in goats with pre-treatment fast. However, no significant differences (P>0.05) were observed in goats on 24 hr and 48 hr pre-treatment fast. Other than C _max, all the kinetic parameters for ABZ-SO2 were significantly higher (P<0.05) in goats on 24 hr and 48 hr pre-treatment fast. Therefore, bioavailability of ABZ was more in goats offered dry fodder and on 24 hr or 48 hr pre-treatment fast. Parasites are exposed to the lethal toxic levels for a longer duration following feeding with grasses with high dry matter content and following 24 and 48 hr fast.