Control of Syphacia obvelata in mice using a combination therapy of albendazole and ivermectin

Pinworm infections globally occur in laboratory rodents. In the present study, infection with Syphacia obvelata was diagnosed in a mouse colony by microscopic examination of perianal impressions using cellophane tape technique. The infection was successfully treated with Tab. Albendol Plus® (albendazole 400 mg + ivermectin 12 mg) administered orally in drinking water for five days on and a week off rotation for five weeks consecutively. In addition, 0.1% Inj. Petmectin® (ivermectin 10 mg/ml) in distilled water was topically sprayed on mice and the same was applied as mist over the cages and bedding once a week for five weeks when the cages were changed in each animal room. The eggs disappeared completely after the second dose and third spray and no eggs were detected even nine months post-treatment, signifying the efficiency of the treatment regimen.