Pharmacokinetics of toltrazuril following single dose administration in poultry

The present study was undertaken to investigate the pharmacokinetics of Toltrazuril in poultry following single dose (7mg.kg^-1) oral administration. The concentration of Toltrazuril in plasma was analysed by High Performance Liquid Chromatography (HPLC). The maximum plasma concentration (C_max ) of 3.383 μg.ml^-1 was obtained. The time to reach C_max (T_max) was 0.28 days (6.72 h) post administration. The volume of distribution (Vd), elimination half life (Beta_HL) and area under curve (AUC) were calculated as 1908.93 ml.kg^-1, 2.30 days, 10.57 day.μg.ml^-1, respectively. It can be concluded from the study that a priming dose of 7.0 mg.kg^-1 with a maintenance dose of 2.5 mg.kg^-1 at every 14 day is recommended in poultry.