Antimicrobial and muscle relaxant potential of leaf extract of sausage tree

The present study investigated the potential of different leaf extracts of Sausage tree (Kigelia africana) as a muscle relaxant in rodents and our aim was also to study in-vitro antibacterial activity of the various extracts from leaves of the plant. Different leaf extracts of Kigelia africana i.e. aqueous, alcoholic, acetone and chloroform were investigated for in-vivo muscle relaxant activity and in-vitro antibacterial activity at the dose rate of 50 mg/kg and 100 mg/kg in Wistar rats. For muscle relaxant activity rota-rod apparatus was used and fall-off time was noted. In-vitro antibacterial activity was assessed against clinical isolates of E.coli and S. aureus using agar well diffusion method. The results showed no significant antibacterial and skeletal muscle relaxant activity in any of the leaf extracts of the plant under study.