Spinosad: Sub-acute genotoxicity studies in mice

The genotoxicity studies of spinosad were conducted using two specific tests viz. MNT and CAs at two dose levels of spinosad administered daily for 28 days i.p. in Swiss albino male mice. Significant difference was observed in Polychromatic erythricyte (PCE) with MN, and total MN cells (PCEs+ NCEs) in spinosad treated group at higher dose level (58 mg/kg body weight) only. However, P/N ratio did not differ from that of saline treated group at any of the dose of spinosad. Spinosad treatment increased the frequency of chromosomal aberrations at higher dose only, though it was non-significant as compared to saline treated group. Spinosad produced mild genotoxic effects when administered @58 mg/kg body weight as revealed by Micronuclei test.