KNP College of Veterinary Science (MAFSU), Shirval, Maharashtra, India- 412801, Maharashtra Animal and Fishery Sciences University (MAFSU), Nagpur, Maharashtra, India- 440006
*Corresponding author e-mail: sushmaghadigaonkar@gmail.com
Online published on 8 April, 2021.
The aim of the present study was to evaluate the protective effect of ethanolic leaf extract of Aegle marmelos Correa. on gentamicin induced nephrotoxicity in Wistar rats. The rats were divided into 4 groups of 12 each, Group A serve as Positive control and Group E vehicle control, while Group B, C, D were orally treated with Gentamicin (40mg/ kg), Gentamicinplus Ethanolic leaf extract of Aegle Marmelos @ 250mg/kg and Gentamicn plus Taurine @ 1000mg/kg respectively for 14days.Gentamicin administration cause elevated Serum alanine aminotransferase(ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), serum creatinine and uric acid values. Administration of ethanolic leaf extract of Aegle marmelos with gentamicin significantly decreased the level of Serum alanine aminotransferase(ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), serum creatinine and uric acid values. There were significant decreased in body weight and increased in organ weight. The result indicates that Aegle marmelos ameliorate the gentamicin induced renal damage in rats.
Aegle marmelos Correa, Gentamicin, Nephrotoxicity, Wistar rats Taurine
