Efficacy of carica papaya against thiacloprid induced histoarchitectural changes in brain and spleen of rats

The study was carried out to investigate efficacy of Carica papaya against thiacloprid induced histoarchitectural changes in brain and spleen of rats. Wistar rats were divided in three groups having six rats in each group. Group I served as control (corn oil administered as vehicle). Group II served as thiacloprid treated group (@ 22.5 mg/kg b.wt. orally) and group III (experimental group) thiacloprid along with papaya leaves extract (@ 252mg/kg b.wt.orally) were administered. The thiacloprid treated groups showed marked neuronal degeneration and congestion of blood vessels in the neuropil of cerebral cortex and exhibited moderate to mild lymphocytic depletion in periarteriolar lymphoid sheaths (PALS) of white pulp in the spleen. Papaya treatment showed improvement in histopathological changes of brain and spleen. The ethanolic extract of Carica papaya has the potential to restore the histoarchitectural changes in brain and spleen caused by sub-acute thiacloprid toxicity.