Journal Of Veterinary Pharmacology And Toxicology
  • Year: 2019
  • Volume: 18
  • Issue: 1

Evaluation of antiurolithic activity of ethanolic extract of tribulus terrestris in wistar rats

  • Author:
  • K.A. Sadariya1,, S.K. Bhavsar2, A.M. Thaker3
  • Total Page Count: 6
  • Page Number: 38 to 43

1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, AAU, Anand-388001, Gujarat

2Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, AAU, Anand-388001, Gujarat

3Former Dean & Principal, College of Veterinary Science and Animal Husbandry, AAU, Anand-388001, Gujarat

*Corresponding author e-mail: dr_kasadariya@yahoo.co.in

Online published on 29 June, 2021.

Abstract

In the present study antiurolithic activity of ethanolic extract of Tribulus terrestris was investigated in wistar rats. Urolithiasis was induced in animals by using ethylene glycol (0.75 % v/v) in drinking water for 28 days. The ethanolic extracts of Tribulus terrestris was administered @ 100, 200 and 400 mg/kg body weight orally for 28 days along with 0.75% ethylene glycol in treatment group, respectively. The mean value of urea, BUN, creatinine, uric acid, calcium and phosphorus significantly decreased in animals treated with 400 mg/kg of ethanolic extract of Tribulus terrestris as compared to control group. Result of the present study revealed that ethanolic extract of Tribulus terrestris possesses significant antiurolithic activity.

Keywords

Antiurolithic activity, tribulus terrestris, Ethylene glycol, Ethanolic extract, Wistar rats