Pharmacokinetics of sulfaquinoxaline following single dose oral administration in poultry

The present study was undertaken to investigate the pharmacokinetics and tissue residue study of sulfaquinoxaline in poultry following single dose (200 and 50mg.kg^-1) oral administration. The concentration of sulfaquinoxaline in plasma and tissues of poultry birds was analyzed by HPLC. The initial peak plasma concentration of 43.845 and 41.369 μg.ml^-1was detected in poultry following single dose 200mg.kg^-1 and 50mg.kg^-1 oral administration, respectively. The volume of distribution, clearance, area under curve (AUC), elimination half- life, T_max and C_max calculated were 1869.75 ml.kg^-1, 55.488 ml.h^-1.kg^-1, 3808.429 μg.ml^-1.h, 34.456 h, 19.87 h and 50.813 μg.ml^-1, respectively, following single dose (200mg.kg^-1)and 632.017 ml.kg^-1, 29.881 ml.h^-1.kg^-1, 1692.282 μg.ml^-1.h, 20.339 h, 8.081 h and 43.473μg.ml^-1, respectively, following single dose (50mg.kg^-1) oral administration of sulfaquinoxaline. Tissue residue studies revealed that after single dose (200 and 50mg.kg^-1) oral administration, sulfaquinoxaline, residues were detected in liver, kidney, muscle, intestine, fat and skin upto 120 h and 96 h, respectively with the highest concentration detected in muscle. Therefore, based upon the present study, a priming dose of 40mg.kg^-1followed by a maintenance dose of 14 mg.kg^-1 is recommended. Withdrawal periods of 6 and 7 days, respectively are recommended after single dose (200mg.kg^-1) and single dose (50mg.kg^-1) oral administration of sulfaquinoxaline.