Intravenous and oral pharmacokinetics of marbofloxacin in layer birds

This is the report on pharmacokinetics of marbofloxacin administered via IV and oral route in layer chickens. Single intravenous and oral dose of marbofloxacin was administered in the six Rhode Island Red (RIR) layer birds at the rate of 2 mg.kg^-1 body weight to study pharmacokinetic parameters. Plasma concentrations of marbofloxacin were measured by High Performance Liquid Chromatography (HPLC) method. Following intravenous administration of marbofloxacin in birds, the mean values of elimination half-life [t_1/2(β)], volume of distribution of drug at steady-state [Vd(ss)] and total body clearance (Cl_B) were 4.25 h, 0.982 L.kg^-1 and 3.009 ml.min^-1.kg^-1, respectively. Following single dose oral administration, peak plasma concentration (0.982 μg.ml^-1) was observed at 1 h. The mean values t_1/2(β), V_d(ss), Cl_B and mean residence time (MRT) were 7.638 h, 2.195 L.kg^-1, 3.757 ml.min^-1.kg^-1 and 8.823 h, respectively. The calculated mean oral bioavailability of marbofloxacin was 76.22 per cent in layer birds.