Evaluation of protective effects of erythrina variegata and spondia spinnata on clinico-hematological profile of rat exposed to sub-chronic cadmium intoxication.

This investigation was undertaken to evaluate ameliorative efficacy of the bark powder of E. variegata (EVBP) and Spondia spinnata (SPBP) against cadmium chloride induced toxic effects in a 90 days trial in terms of body weight gain, clinical signs and hematology in Wistar albino rats. Forty-two, six-month-old, albino Wistar rats, weighing 170-200gm, were randomly and equally allocated into seven groups. For 90 days trial, group I served as control. Groups II, III, IV, V, VI and VII were given cadmium chloride @100mg/L of drinking water. Group II served as negative control. Simultaneous treatment was given as silymarin@100mg/kg bwt in group III and EVBP and SPBP @ 1 and 2% in groups IV, V, VI and VII, respectively, in feed for 90 days. No clinical sign was observed except curved spine or lordosis in Cd treated group II. Change in body weight, clinical sings and haematological parameters were examined at day 0, 30, 60 and 90. There was a significant (P<0.05) decline in body weight, haematological parameters Hb, PCV, TEC, TLC and DLC in Cd treated groups whereas a significant elevation in these parameters was observed in treatment groups as compared to Cd treated group II. SPBP and EVBP significantly ameliorated haematological and prevented any clinical signs and body weight. It is concluded from this study that EVBP and SPBP @1 and 2 % in feed ameliorated the cadmium chloride, given @ 100 ppm in drinking water, induced hemo-toxicity and prevented clinical signs and body weight decline, following simultaneous oral administration for 90 days in rats.