Safety evaluation of repeated oral administration of gemifloxacin and piperine in layer birds

The present study was designed to investigate safety of gemifloxacin and piperine @ 10 mg/kg/day orally for 5 days in layer birds. It was carried out by monitoring clinical observations, hematological (TEC, HB, PCV, MCV, MCH, MCHC, TLC, DLC and platelet count) and blood biochemical parameters (blood glucose, ALT, AST, ALP, LDH, serum creatine kinase, serum total bilirubin, serum total protein, serum albumin, serum uric acid and serum creatinine). There were no clinical signs of adverse reactions and all the hemato-biochemical parameters were found to fluctuate within normal range during treatment period and the values were not significantly different from corresponding control day (0 day) values. It suggests that repeated oral administration of gemifloxacin or piperine alone daily once for five days is safe in layer birds.