Evaluation of Biochemical profile of Erythrina variegata and Spondias pinnata following cadmium intoxicated rats

This experiment was designed to evaluate protective efficacy by assessing biochemical profilefollowing 90 days feeding of the bark powder of Erythrina variegata (EVBP) and Spondia spinnata (SPBP), respectively, against simultaneously administered cadmium chloride in drinking water for 90 days in Wistar albino rats. Forty-two, six-monthold, rats, weighing 170-200gm, were randomly and equally divided into seven groups. Group I served as control. Groups II, III, IV, V, VI and VII were given cadmium chloride @100mg/L of drinking water. Group II was given cadmium chloride alone which served as negative control. Simultaneous treatment was given as silymarin@100mg/kg bwt in group III, EVBP @ 1 and 2% in groups IV and V, and SPBP @ 1 and 2% in VI and VII, respectively, in feed for 90 days. Biochemical parameters were examined at 0, 30, 60 and 90 days intervals. Asignificant increase in biochemical parameters AST, ALT, ALP: G ratio, BUN and creatinine, and reduction in total proteins, albumin and globulin were observed in Cd intoxicated rats after 90 days.SPBP and EVBP treated groups showed significant (P<0.05) improvement in most of the biochemical parameters as compared to Cd-treated rats, however, non significantameliorationwas observed in AST,ALT, ALP, BUN and creatinine values. It is concluded from this study that EVBP and SPBP @1 and 2 % in feed ameliorated the cadmium chloride, given @ 100 ppm in drinking water, induced biochemical parameters, following simultaneous oral administration for 90 days in rats.