Synthesis and study of antioxidant activity of nickel nanoparticles in concentration and time dependent manner

Oxidative stress due to production of excess amount of reactive oxygen species has lead to occurrences of pathological problems of plants, animals and human beings. The safety issues related to the synthetic antioxidants has leaded the research for development of some alternative antioxidants. In view of this, nickel (Ni) nanoparticles were synthesized by chemical method in present study. The suspensions of nanoparticles at different concentrations were assayed against different in vitro radicals (ABTS, DPPH, superoxide anion and hydrogen peroxide radicals) on day 1, 30 and 60 to evaluate their antioxidant potentials. The average size of Ni nanoparticles synthesized in this study was of 104.26 nm. Their polydispersity index was 0.324. The different free radicals were scavenged by Ni nanoparticles in concentration dependent manner and their scavenging potentials decreased on day 30 and 60. The IC₅₀ values of Ni nanoparticles against all the free radicals were lesser on day 1 as compared to day 30 and 60. In conclusion, the antioxidant potentials of Ni nanoparticles as a synthetic antioxidant may be explored to counter the various problems of Veterinary sciences, Medical sciences, agriculture, food sciences, etc. after conducting further detailed studies in future.