Acute toxicity study of ivermectin in wistar Rats

The study was conducted on wistar rats to observe the potential of ivermectin (Ivermic super®,1 % w/v) for causing acute toxicity. No mortality was observed following single dose subcutaneous administration of ivermectin in test group I (0.25 mg/kg b.w; ), II (1 mg/kg b.w), III (2.5 mg/kg b.w), and IV (5 mg/kg b.w). A control group was kept for comparison with treatment group. The rats of group IV showed CNS symptoms such as tremors, ataxia and marked depression in movement and activity. No significant changes in the Hb, PCV, TEC and TLC of test groups I, II, and III could be observed as compared to control group. There was significant (P<0.01) decrease in Hb (11.95±0.07) and PCV (38.1± 0.03) value of group IV as compared to control group. No significant changes in the protein profile (Total protein, Albumin, Globulin and Albumin: Globulin) of test groups could be observed as compared to control group. Glucose value in rats of group IV (139.76 ± 6.8) showed significant (P<0.01) increase as compared to control group. The values of Creatinine in rats of group III (1.13 ± 0.22) and group IV (1.50 ± 0.02) showed significant increase (P<0.01) as compared to control group. No significant changes were observed in urea of test groups as compared to control group. The values of SGOT (76.8±1.11) and SGPT (35.78 ± 0.70) in rats of group IV showed significant increase (P<0.01) as compared to control group. No important gross lesion was observed in viscera or the internal organs of the rats in all the five groups.