Journal Of Veterinary Pharmacology And Toxicology
  • Year: 2020
  • Volume: 19
  • Issue: 1

Antiurolithiatic potential of Tribulus terrestris on ethylene glycol-induced urolithiatic Rats

  • Author:
  • K.A. Sadariya1,, S.K. Bhavsar2, A.M. Thaker3
  • Total Page Count: 7
  • Page Number: 61 to 67

1Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, AAU, Anand-388001, Gujarat

2Professor & Head, Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, AAU, Anand-388001, Gujarat

3Former Dean & Principal, College of Veterinary Science and Animal Husbandry, AAU, Anand-388001, Gujarat

*Corresponding author: dr_kasadariya@yahoo.co.in

Online published on 11 August, 2021.

Abstract

Present study was planned to evaluate antiurolithiatic activity of chloroform extract of Tribulus terrestris in male wistar rats. Urolithiasis was induced in rats by using ethylene glycol (0.75 % v/v) in drinking water for 28 days. The chloroform extracts of Tribulus terrestris was administered @ 100, 200 and 400 mg/kg body weight orally for 28 days along with 0.75% ethylene glycol in treatment group, respectively. The mean value of serum biochemical parameters like urea, BUN, creatinine, uric acid, calcium and phosphorus significantly decreased in animals received 400 mg/kg of Tribulus terrestris chloroform extract as compared to control rats. Observation of the present study indicated that chloroform extract of Tribulus terrestris possesses significant antiurolithiatic activity.

Keywords

Antiurolithiatic potential, Tribulus terrestris, Chloroform extract, Urolithiatic rats