Journal Of Veterinary Pharmacology And Toxicology

The present study was planned to evaluate the effect of repeated dose intravenous (IV) administration of marbofloxacin (5 mg/kg, 5 days) on hematological and biochemical parameters changesin broiler chickens. At 6th day, after repeated IV administration of marbofloxacin, mean hemoglobin (HB), packed cell volume (PCV) and total leukocyte count (TLC) werenon-significantly different as compared torespective values at day 0 (before drug administration). Total erythrocyte count (TEC) and lymphocyte count at 6th day were 2.35 ± 0.08×10⁶/μl and 56.67 ± 1.26 %, respectively which significantly (p < 0.05) lower than respective values of 2.57 ± 0.05×10⁶/μl and 62.83 ± 2.20 % at 0 day. Whereas, heterophil count was significantly (p < 0.05) increased from day 0 (25.17 ± 1.45 %) to day 6 (29.83 ± 1.01 %) after repeated administration of marbofloxacin. However, these hematological alterations were in the normal clinical range of broiler chickens. Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin (MCH) were also non-significantly different as compared to day 0. At 6th day, no significant differences were observed in biochemical parameters viz. aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), total protein, albumin, globulin, blood urea nitrogen (BUN), total bilirubin and creatinine as compared to day 0. The findings of the present study indicated that marbofloxacin in present dosage regimen was found to be safe and well tolerated in broiler chickens.