Safety of gemifloxacin following co-administration with piperine and in piperine pretreated layer birds

The present study was conducted to investigate safety of oral gemifloxacin after piperine pretreatment and coadministartion with piperine @ 10 mg/kg once daily for 5 days in layer birds. Safety evaluation was carried out by monitoring clinical observations, hematological (TEC, HB, PCV, MCV, MCH, MCHC, TLC, DLC and platelet count) and blood biochemical parameters (blood glucose, ALT, AST, ALP, LDH, serum creatine kinase, serum total bilirubin, serum total protein, serum albumin, serum uric acid and serum creatinine). There were no clinical signs of adverse reactions and all the hemato-biochemical parameters were found to fluctuate within normal range during treatment period and the values were not significantly different from corresponding control day (0 day) values. It suggests that repeated oral administration of gemifloxacin after piperine pretreatment or in combination with piperine daily once for five days is safe in layer birds.