The cardioprotective efficacy of Cichorium intybus against imidacloprid induced cardiotoxicity in wlh chicks

The present research work was designed with the aim to evaluate the cardioprotective efficacy of Cichorium intybus in the birds fed imidacloprid @ 100 ppm in feed by determining the myocardial biomarker CK-MB . For the present study, thirty male white leghorn chicks weighing 300-350 gm of 6-8 weeks of age were divided equally and randomly into five groups viz. I, II, III, IV and V. Group I served as control. Other groups were fed medicated ration containing Cichorium intybus leaf powder (CILP) @ 5000 ppm in group II, imidacloprid (IM) @ 100 ppm in group III, imidacloprid (IM) @ 100 ppm plus silymarin (SM) @100 ppm in group IV and imidacloprid (IM) @100 ppm plus Cichorium intybus leaf powder (CILP) @ 5000 ppm in group V, respectively, for 8 weeks in WLH cockerels. The blood samples were collected at the end of 4th and 8th week respectively, for CK-MB estimation. A significant (P<0.05) increase in CK-MB levels was seen in group III as compared to control group indicated cardiotoxic effect of imidacloprid in chicks. A significant (P<0.05) reduction in CK-MB levels in groups IV and V was observed as compared to group III. Moreover, group II fed Cichorium intybus alone revealed a significant (P<0.05) reduction in CK-MB levels as compared to control group I suggesting its cardioprotective effect. Thus, it is concluded from this study that the administration of Cichorium intybus @ 5000 ppm in WLH cockerels showed its protective efficacy against imidacloprid induced cardiac damage.