Protection by Amaranthus hypochondriacus Against arsenic induced nephrotoxicity in wlh cockerels

The aim of this study was to evaluate the nephroprotective of seed powder of Amaranthus hypochondriacus (SPAH) following oral administration @ 8000 ppm in simultaneously fed arsenic(AR) @ 110 ppm in feed for 60 days in WLH cockerels. Thirty WLH cockerels were equally and randomly divided into 5 groups with 6 birds in each group. Group I served as control and group II arsenic @ 110 ppm, group III SPAH@8000 ppm, group IV AR @ 110 ppm plus silymarin @ 100 ppm and group V AR @ 110 ppm plus SPAH @ 8000 ppm served as treatment groups for 60 days of feeding trial study. A significant (P<0.05) increase in values of creatinine and BUN was observed in arsenic treated group II, which were restored by SPAH group V towards normal. Group III revealed values of creatinine and BUN were at par with control group I and showed potentiating effect of SPAH when given alone.Thus, it is concluded from the present study that arsenic @ 110 ppm produced nephrotoxic effect after 60 days treatment in WLH cockerels which were reversed following medication with seed powder of A. hypochondrioacus (SPAH) @ 8000 ppm in feed for 60 days in WLH cockerels.