1Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal SciencesLala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125004, Haryana, India
2Principal Scientist, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal SciencesLala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125004, Haryana, India
3Professor and Head(Retd.), Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal SciencesLala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125004, Haryana, India
*Corresponding author Email - archana.lohiya@gmail.com
Online published on 1 February, 2022.
Technical grade of imidacloprid was evaluated for its effect on oxidative stress and level of reproductive hormone, progesterone, in blood of female Wistar rats. Plasma malondialdehyde (MDA), blood reduced glutathione (GSH), erythrocyte superoxide dismutase (SOD) activity and serum progesterone were estimated in female rats at two dose levels (19 and 38 mg/kg/day) administered for 10, 20 and 30 days, respectively. Effects were compared with respective control animals administered daily with 2% gum acasia (1ml/100g b.wt.) for 10, 20 and 30 days. Imidacloprid at 38 mg/kg/day has produced significant increase in levels of plasma MDA in rats administered drug daily for 30 days. However, GSH levels show significant decrease in blood in 20 and 30 days group at higher dose. Imidacloprid at 38 mg/kg/day has decrease significantly SOD activity in erythrocytes of 20 and 30 days group. Imidacloprid 38 mg/kg/day dose has also produced significant alterations in the levels of serum progesterone. Imidacloprid at 19 mg/kg/day has not produced changes in any dose group. Therefore, it is concluded that imidacloprid has generated oxidative stress at 38 mg/kg/day administered daily for 20 and 30 days in female Wistar rats.
Imidacloprid, Oxidative stress, Blood, Progesterone, Wistar rats
