1Joint Director, Deptt. of Animal Husbandry, Govt. of Uttarakhand
2Professor, Department of Pharmacology and Toxicology; CVASc. G.B. P.U.A & T. Pantnagar263145, Uttarakhand, India
3PhD Scholar, Department of Pharmacology and Toxicology; CVASc. G.B. P.U.A & T. Pantnagar263145, Uttarakhand, India
*Corresponding author Email: drsapnamishra@gmail.com
Online published on 1 February, 2022.
The present study was designed to assess the ameliorating potential of dried powder of Eclipta alba plant (DPEA) on antioxidant parameters against arsenic induced toxicity in white leghorn cockerels. Arsenic was given and DPEA in two doses @ 1000 ppm and 2000 ppm in feed for 90 days to evaluate its antioxidant efficacy by determining antioxidant parameters. Thirty five cockerels were divided randomly and equally into five groups viz. Groups I served as control, II for arsenic in the feed @100ppm, III for arsenic@100ppm + silymarin, IV for arsenic@100ppm + DPEA @1000ppm and V, arsenic@100ppm + DPEA @2000ppm in feed for 90 days. Antioxidant parameters such as levels of LPO, GSH and SOD in RBCs at 30, 60 and 90 days interval and LPO and SOD in tissues after completion of trial at 90 days were determined. Arsenic enhanced lipid per oxidation and reduced GSH, SOD levels and DPEA @2000ppm significantly (P<0.05) reversed these parameters as compared to silymarin. In tissues, DPEA significantly (P<0.05) restored the values of LPO, GSH and SOD altered by arsenic intoxication. DPEA2000 showed better protective efficacy than DPEA1000 The study revealed that dried powder of Eclipta alba produced ameliorative efficacy against arsenic induced oxidative stress in cockerels.
Antioxidant, Eclipta alba, Lipid peroxidation, Reduced glutathione, Superoxide dismutase, White leghorn cockerels
