1Joint Director, Deptt. of Animal Husbandry, Govt. of Uttarakhand
2Professor, Department of Pharmacology and Toxicology; CVASc. G.B. P.U.A & T. Pantnagar263145, Uttarakhand, India
3PhD Scholar, Department of Pharmacology and Toxicology; CVASc. G.B. P.U.A & T. Pantnagar263145, Uttarakhand, India
*Corresponding author Email: drsapnamishra@gmail.com
Online published on 1 February, 2022.
The present study was designed to assess the immunomodulatory potential of dried powder of Eclipta alba plant (DPEA) in arsenic intoxicated white leghorn cockerels. The dried powder of Eclipta alba (DPEA) was prepared from the whole plant. Thirty five cockerels were divided randomly and equally into five groups viz. Groups I served as control, II for arsenic only, III for arsenic (100 ppm)+ silymarin (250 ppm), IV for arsenic (100 ppm)+ DPEA @1000 ppm and V, arsenic (100 ppm)+ DPEA @2000 ppm for 90 days. Immunomodulatory potential was evaluated by determining lymphocyte proliferation by measuring OD for cellular immunity and estimation of serum levels of immunoglobulins for humoral immune response. There was a significant (P<0.05) decrease in the values of OD in group II, III, IV and V as compared to control after 90 day of trial. Total immunoglobulins were significantly (P<0.05) reduced in all the groups at 90 days feeding interval as compared to 60 days. The suppression in immune response was observed in the arsenic treated group, however, DPEA showed immunomodulatory effects by restoring the altered levels.
Arsenic, Immunomodulation, Lymphocyte proliferarion, Delayed type hypersensitivity, WLH cockerels
