Effect of amikacin after intravascular administration at therapeutic dosage on haemo-biogram profile in goats

The amikacin is most widely used semisynthetic aminoglycoside with relatively low therapeutic index. The use at therapeutic doses may lead to adverse changes in haemo-biogram profile. The aim of the present study was to determine the changes in some haemo-biogram profile on 1^st, 3^rd, 5^th and 7^th days after intravascular administration with amikacin at therapeutic dose @10 mg/kg bwt for 5 days in four healthy non lactating female goats. The results of present studies indicated that at the therapeutic doses of amikacin, caused significant (p < 0.05) rise in serum blood urea nitrogen and creatinine levels on 5^th and 7^th day, but no significant changed observed in blood haemoglobin (Hb), packed cell volume (PCV), total erythrocytes count (TEC), total leucocyte count (TLC), lymphocyte, monocyte, eosinophil, basophil and neutrophil and the serum albumin, globulin, total protein, bilirubin, cholesterol and triglyceride level during the treatment. Amikacin also caused significant (p < 0.05) rise in serum enzyme viz. alanine amino transferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels on 3^rd or 5^th day. On the whole, the results of these studies demonstrate that amikacin have potential to change the haemo-biogram profle of female goats after administration of amikacin at therapeutic dosage.