Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh, Gujarat, India
*Corresponding author Email: chiragvets@yahoo.co.in
Online Published on 24 November, 2022.
The study was to evaluate the harmful effects of acrylamide on female zebrafish after exposure to ACR at concentrations of 0.152, 0.305, 0.610 and 1.22 mM for 21 days. Fish subjected to a dose of 1.22 mM concentration died after six days, while those that survived exhibited a progressive increase in toxic symptoms. Widening intercellular gaps and the accumulation of proteinaceous fluid were seen in ovarian depletion of yolk granules in mature oocytes. The natural prismatic structure of the intestine was lost, resulting in goblet cell hyperplasia and enterocyte exfoliation. In conclusion, acrylamide has a wide range of toxic effects on the reproductive and digestive systems.
Acrylamide, Zebrafish, Histopathology, Ovary, Intestine
