Pharmacokinetic study of enrofloxacin following single dose oral administration in broiler poultry

The pharmacokinetics of enrofloxacin after oral administration as a single dose @ 10 mg.kg⁻¹b.w. in broilerswas examinedand an appropriate dosing regimen was developed. Blood samples were taken at various intervals and the concentration of enrofloxacin in plasma was determined using high performance liquid chromatography (HPLC). The distribution phase rate constant (a) was 1.173h⁻¹and distribution half-life (t_1/2a) was 0.582h. The elimination rate constant (p) was calculated to be 0.1 h⁻¹and the elimination half-life (t) was calculated to be 13.2h. The volume of distribution of central compartment (V_c) and the volume of distribution of peripheral compartment (V_p) were calculated as 6.609 L.kg⁻¹and 8.530L.kg⁻¹, respectively. Enrofloxacin displayed a plasma clearance (Cl_P) of 0.826 L.kg⁻¹.h⁻¹ and a total body clearance (Cl_B) of 4.126 L.kg⁻¹.h⁻¹, respectively. The peak plasma concentration (C_max) was calculated to be 1.535p.gmL⁻¹ and time required to achieve maximum plasma concentration (T_max) was calculated as 1.0h. The mean area under the plasma concentration time curve (AUC) was calculated to be 15.522μg.h.mL⁻¹.