M.V.Sc. Thesis work, Department of Veterinary Pharmacology and Toxicology, College of Veterinary & Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand
*Corresponding author email: drsrinivasgirish@gmail.com
Online Published on 24 November, 2022.
This study was undertaken to investigate the toxicity of enrofloxacin and ciprofloxacin by estimating blood oxidant parameters in rats. Thirty six Wistar rats of 8 weeks weighing 250-300gms were divided equally and randomly into six groups viz. I, II, III, IV,V and VI. Group I served as control and cyclophosphamide was given @ 20 mg/kg b wt, i.p. 24 h prior to sacrifice in group II. Other groups were given as enrofloxacin @75mg/kg b wt in group III and @ 150 mg/kg, b wt, p.o, in group IV, ciprofloxacin @ 50mg/kg b wt in group V and @ 100mg/kg b wt group in VI, p.o., for 28 days. A significant (p<0.05) increase in GSH, SOD and catalase activity and an increase in LPO in RBCs were observed in groups II, III and V as compared with control group I. It is concluded from this study that enrofloxacin and ciprofloxacin at high doses produced oxidative stress in rats after 28 days.
Cyclophosphamide, Ciprofloxacin, Enrofloxacin, Oxidative Stress
