In vitro Antioxidant Activity of 1, 5- Benzodiazepine Derivatives by Organo Catalysed Microwave Assisted Three Component Reaction

The search for novel compounds with antioxidant activity has gained significant attention in recent years due to their potential therapeutic applications in various oxidative stress-related diseases. In this study, we aimed to evaluate the antioxidant activity of 1, 5-benzodiazepine derivatives produced by an organo-catalyzed microwave-assisted three-component reactions. The synthesis of 1, 5-benzodiazepine derivatives was achieved using an efficient and eco-friendly organo-catalytic approach, combined with the application of microwave irradiation. The reaction involved the condensation of an aromatic aldehyde, an phenylenediamine, and a β—ketoesters, resulting in the formation of diverse benzodiazepine derivatives. The synthesized compounds were then subjected to antioxidant activity evaluation using various in vitro assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power and chelating activity. Preliminary results demonstrated that these synthesized 1, 5-benzodiazepine derivatives exhibited little antioxidant activity.