Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar - 385 506 (Gujarat, India)
The present study was conducted to investigate the pharmacokinetic properties of danofloxacin in rabbits. Plasma concentrations of danofloxacin were determined by ultra-high performance liquid chromatography (UHPLC). Pharmacokinetic parameters were derived from plasma concentrations and time data using PK Solver 2.0 software. After a single intravenous injection of danofloxacin at 5.0 mg/kg body weight, the elimination rate constant (2) values ranged from 0.14 to 0.18 1/h, with a mean value of 0.16 1/h. The calculated mean value of the corresponding half-life (t1/22) was 4.31 h, with a range from 3.94 to 4.96 h. The mean value for the area under the curve (AUC) of plasma concentration of danofloxacin versus time was 6.09 μg.h/mL, and the mean value for the area under the first moment of plasma concentration (AUMC) was 22.44 1/4g.h2 /mL. The mean residence time (MRT) averaged 3.68 hours. The mean apparent volume of distribution (Vd(area)) and steady-state volume of distribution (Vd(ss)) were 5.12 and 3.03 L/kg, respectively. The mean value of total body clearance (ClB) was 0.82 L/kg/h.
Danofloxacin, Intravenous, Pharmacokinetics, Rabbit, UHPLC
