Evaluation of anticancer activity of Neolamarckia cadamba against dmba-induced mammary tumor in wistar rats using ultrasonography

The present study was conducted to see the effects of methanolic extract of stem bark of Neolamarckia cadamba on DMBA-induced mammary tumours in Wistar rats. Forty rats were orally administered with DMBA at a dose rate of 20 mg/ kg body weight 3 times a week for 5 weeks. The induced tumour was confirmed using ultrasonography after 60 days of induction. Rats that confirmed tumour development were divided into 4 groups comprising six rats in each group (T2 and T5). Group T1 rats were normal controls. Group T2 was positive control andreceived no treatment after tumour development. Group T3 was treated with the standard reference drug Tamoxifen at a dose rate of 3.3 mg/kg body weight. Groups T4 and T5 were treated with methanolic extract of stem bark of Neolamarckia cadamba at a dose rate of 200 and 400 mg/kg body weight, respectively. Ultrasonography was conducted before, and after treatment, revealing regression of mammary tumours in the treatment groups (T3, T4, and T5). The highest regression was observed in tumour control, followed by NC @ 400 mg/ kg BW, which showed greater tumour regression than NC @ 200 mg/kg BW. These findings highlight the positive effects of the methanolic extract of Neolamarckia cadamba stem bark against DMBA-induced mammary tumours, suggesting its potential as a supportive therapeutic option.