Ethnopharmacological approach of wound healing with special reference to multi drug resistant Staphylococcus aureus

Wound injury is defined as a disruption of the tissue’s anatomical, cellular, and functional integrity. Wound healing begins as soon as an injury occurs and continues depending on the severity of the injury. Often wound healing gets delayed due to many reasons of which wound infections are a major cause. Infection of a wound with multidrug resistant Staphylococcus aureus has been a global public health issue. Antibiotic resistance to S. aureus has demonstrated that there is no long-term treatment for this infection. This is due to the small number of antibacterial medication classes available, as well as the common emergence of cross-resistance within and between them. In many countries, including India, most therapies for MDRSA, which is widespread in the skin and wound infections, must rely on second-line medications and routine prophylaxis with first-line antibiotics for orthopaedic and other surgical operations have minimal efficacy in many cases. Second-line antibiotics for S. aureus are more expensive and have more severe side effects. Identification of appropriate natural chemicals from medicinal plants is one of the possible ways. The purpose of this review is to offer herbal remedies and their methods of action in the treatment of MDRSA infected skin wounds, as well as to provide information for the development of more effective wound-healing medications.