LS - An International Journal of Life Sciences
  • Year: 2012
  • Volume: 1
  • Issue: 3

Radiofrequency Electromagnetic Field Exposure Effects on Antioxidant Enzymes and Liver Function Tests

  • Author:
  • Kajal Kumari1, Ramovatar Meena2, Shivendra Kumar1, Paulraj Rajamani3, Hriday Narayan Verma4, Kavindra Kumar Kesari5,
  • Total Page Count: 7
  • Published Online: Dec 1, 2012
  • DOI:
  • Page Number: 238 to 244

1Research Scholar, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi-110067, India

2Research Scholar, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi-110067, India

3Assistant Professor, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi-110067, India

4Professor, School of Engineering and Technology, SADTM campus, Jaipur National University, Jaipur, Rajasthan, India

5Assistant Professor, School of Engineering and Technology, SADTM campus, Jaipur National University, Jaipur, Rajasthan, India

*E-mail id: kavindra_biotech@yahoo.co.in

Abstract

Electromagnetic fields have adverse effects as a result of widespread use of electromagnetic radiations on biological systems. The aim of this study was to investigate the effect of mobile phone and microwave (MW; 2.45 GHz) radiation on the oxidative status of liver. In present study, 70-day-old male Wistar rats (200 ± 20 g) were used. Animals were divided in two groups: exposed and sham exposed (n = 6 in each group). Animals were exposed at two different frequencies of mobile phone and 2.45 GHz of MWs. Exposure was given for 2 h a day for 35 days. The effect of these radiations were observed in activities of liver antioxidant enzymes glutathione peroxidase (GPx, superoxide dismutase (SOD), catalase (CAT), and concentration of malondialdehyde (MDA) as an indicator of lipid peroxidation and serum biochemical parameters (total bilirubin, alkaline phosphate, aspartate aminotransferase and alanine aminotransferase) related to liver functioning tests (LFT). Result shows that exposure to mobile phone and MW radiations decrease the level of GPx and SOD in exposed group as compared to sham-exposed group. While CAT level was found to be increased in exposed group as compared to sham exposed. Meanwhile, elevated level of MDA and changes in liver function parameters were also observed in mobile phone and MW-exposed groups by comparing to control ones. The study concludes that the chronic exposure to these radiations adversely affect the liver functioning and may be an indication of possible tumour promotion due to significant (P<0.05) changes occur in antioxidative enzymes.

Keywords

Antioxidants, Microwave radiation, MDA, Mobile phone radiation, LFT