A Comparative Study of Hypoglycaemic Effect of Different Crude Extracts Isolated from Aloe Vera

Indian medicinal plants used in the Ayurveda traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. α-Amylase inhibitors offer an effective strategy to lower the level of postprandial hyperglycaemia via control of starch breakdown. Aloe vera has been considered as a hypoglycaemic agent. In the study, we compared the α-amylase inhibitory activity of different crude extracts isolated from Aloe vera leaves in two districts of Rajasthan - Jaipur and Bharatpur - which sear approximately similar climatic conditions. The α-amylase inhibitory activities were evaluated by both qualitative and quantitative assays. Results showed that ethanolic extracts have very high ant-diabetic potential in both districts than other crude extracts. The IC₅₀ value of ethanolic extracts are 0.316 and 0.323 mg/ml in the Jaipur and Bharatpur districts, respectively. In both the districts, results showed few variations due to climatic and some other effects.