Antibacterial, Antioxidant and Anticoagulant Efficacy of C. verum Mediated Silver Nanoparticles

The objective of this work is to synthesis silver nanoparticles using Cinnamon bark extract as the reducing agent and its antibacterial, anticoagulation and antioxidant activity was studied. The green silver nanoparticles were monodisperse, spherical and 70 nm in diameter. A positive antibacterial activity against Pseudomonas, Pseudomonas aeruginosa was found in both methanol extract and silver nanoparticles. The maximum relative inhibitory zone is 94% as observed in AgNp. The FRAP antioxidant activity of cinnamon was 400 pM at 100 pg/ml and 700 pM by green AgNp. in vitro anticoagulant activity of AgNp was confirmed at 10 pg/ml. The AgNPs exhibited profound anti-coagulant activity as compared to heparin. Even though several anticoagulants have been reported from biological sources, only a few nanoparticles have been reported as anti- coagulant and thrombolytic activities. Further characterization of the capping agent and stability of AgNp are needed to find out the efficiency of AgNp as anticoagulant.