Accelerated elimination with Charcoal Hemoperfusion in Acute Phenobarbital Intoxication: A case report

Phenobarbital is long acting barbiturate with low lipid solubility that act as central nervous system depressants and used as anticonvulsant, sedative, hypnotic drug. In acute severe barbiturate intoxication, through CNS depression, coma, respiratory arrest and hypotension may occur, which are the major causes of mortality. Mortality is high for blood levels over 80 micro/mL and the lethal dose in adult is estimated as 6 to 10 gram. We report a case of Phenobarbital intoxication in a 24 years old female, with history of consumption of 120 tablets of phenobarbitone of 60 milligram each (7.2 gram) who was successfully treated by emergency charcoal hemoperfusion.