A Study on Grading and Severity of Aortic Athermatous Plaques-Autopsy based Study

Atherosclerosis is a complex (disease of the large and medium sized arteries) process that involves lipoprotein influx, lipoprotein modification, increased prooxidant stress and inflammatory, angiogenic and fibroproliferative responses intermingled with extra cellular matrix and lipid accumulation resulting in the formation of an atherosclerotic plaque. Endothelial dysfunction is common in atherosclerosis and often manifests as a reduced vasodilator or enhanced vasoconstrictor phenotype which contributes to luminal compromise. Thrombosis resulting from plaque rupture or superficial erosion complicates atherosclerosis often resulting in abrupt luminal occlusion with resultant acute ischemic syndromes. Infectious agents may contribute to the inflammatory response and thus to destabilization of the lesions. An improved understanding of the patho physiology of atherosclerosis providing novel direction for its prevention and treatment. ⁽⁷⁾ Acceleration of Atherosclerotic process leading to macrovascular disease. The Study is prospective and one Hundred Aortas are examined from the different age groups of males and females, during the medico legal Autopsies and the results are statistically analysed.